Organoids missing the TSC2 gene form rogue astrocytes; and more
thetransmitter.org
Organoids missing the TSC2 gene develop overactive astrocytes similar to those in tubers from individuals with tuberous sclerosis complex, suggesting glial dysfunction driven by mTORC1 signaling, rather than seizures, contributes to the condition. The study highlights reactive astrocytes as potential therapeutic targets for TSC-related neuropathology.
All articles from 30 September 2026. Summaries are AI-generated and may contain errors; the linked article is the authority.