Loss of interneuron plasticity may be shared hallmark of neurodevelopmental conditions
thetransmitter.org
A new study identifies the loss of experience-dependent plasticity in hippocampal PV interneurons as a shared biological mechanism underlying various neurodevelopmental conditions like autism and epilepsy. Researchers found that mouse models of these disorders fail to upregulate the plasticity gene MEIS2 after social experiences, leading to cognitive impairments and seizures. However, restoring this gene expression in adulthood successfully improved memory and reduced seizure frequency in the affected mice.
All articles from 13 August 2026. Summaries are AI-generated and may contain errors; the linked article is the authority.