Cognitive and synaptic impairment induced by deficiency of autism risk gene Smarcc2 and its rescue by histone deacetylase inhibition
Nature
Deficiency in the autism risk gene Smarcc2 causes cognitive and synaptic impairments by reducing histone acetylation and downregulating synaptic genes. However, treatment with the HDAC inhibitor romidepsin successfully restored these molecular deficits and rescued working memory in mouse models. These findings indicate that targeting histone deacetylase activity can alleviate neurodevelopmental disorders associated with Smarcc2 deficiency.
All articles from 27 August 2026. Summaries are AI-generated and may contain errors; the linked article is the authority.